Pharma

Eli Lilly’s GLP-1 pill aces late-stage trial days after Pfizer pulls theirs

The pharma giant said its oral GLP-1 drug demonstrated significant efficacy results and a safety profile consistent with its other GLP-1 products.

Heerea Rikhraj

April 17, 2025

1:34 pm

Credit: Getty Images / Picture Alliance

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Just days after Pfizer pulled its experimental obesity pill, Eli Lilly announced promising results for its oral GLP-1.

The pharma giant announced Thursday morning that its oral GLP-1 drug advanced through the first round Phase 3 testing with positive results.

Lilly’s oral drug, orforglipron, is a small molecule GLP-1 pill that can be taken once a day without any food or water restrictions to manage diabetes and weight loss.

The pill is being investigated in three formulas — 3mg, 12mg and 36mg.

Overall, the study results were strong enough for Lilly to continue pursuing testing the drug. The company said it expects to submit the drug for regulatory testing for weight loss management by the end of the year.

If approved, Lilly may gain a large size of the oral GLP-1 market, which is projected to be worth more than $50 billion by the early 2030s.

Lilly CEO David Ricks celebrated the success of the trial, noting that the company is ready to launch the drug worldwide, if approved by regulators.

“We are pleased to see that our latest incretin medicine meets our expectations for safety and tolerability, glucose control and weight loss, and we look forward to additional data readouts later this year,” Ricks stated. “As a convenient once-daily pill, orforglipron may provide a new option and, if approved, could be readily manufactured and launched at scale for use by people around the world.”

Following the announcement, Lilly’s stock was up 16.1% as of Thursday afternoon.

If approved, the drug is poised to compete against Novo Nordisk’s Rybelsus, the only oral GLP-1 drug on the market targeting diabetes and weight loss.

Last year, Rybelsus generated $3.38 billion in sales and is expected to exceed $6.8 billion in sales by 2030.

The drug also comes in different doses, and averages a reduction of between 1% (for the 7mg tablet) and 1.3% (for the 14mg tablet) in A1C or blood sugar levels.

So far, primary endpoint results from orforglipron seem to exceed those of Rybelsus. In a statement, Lilly noted that the drug lowered A1C levels on average by 1.3% to 1.6%.

More than 65% of the study’s participants taking the highest dose of orforglipron (36mg) achieved an A1C level less than or equal to 6.5%, below the current threshold for diabetes defined by the American Diabetes Association.

As for weight loss, patients taking Novo’s Rybelsus lost an average of 4.8 pounds with the 7mg drug and 6.8 pounds with the 14mg pill.

Lilly’s study found that orforglipron achieved similar weight loss numbers, but from lower dosages of the drug.

The 3mg pill achieved an average weight loss of 4.5%, the 12mg averaged weight loss of 5.8% and the 36mg pill averaged 7.6%.

Following Lilly’s announcement, Novo’s stock sank by 7%.

Additionally, the news came days after Pfizer announced it will be abandoning its oral GLP-1 drug, dangulipron, after a patient in a study sustained a liver injury that was said to be potentially connected to the drug.

Lilly noted that the safety profile of orforlipron was consistent with its other GLP-1 products on the market.

The most common adverse effects of the oral drug included mild to moderate gastrointestinal related adverse events like diarrhoea, constipation and vomiting.

Discontinuation of the drug during studies due to adverse effects were below 10% for all three formulation doses.

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Eli Lilly’s GLP-1 pill aces late-stage trial days after Pfizer pulls theirs

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