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Takeda nabs AC Immune Alzheimer’s therapy for $100M upfront

Takeda is adding ACI-24.060 to its pipeline. The Alzheimer’s therapy targets amyloid beta buildup in the brain and is currently being investigated in a Phase 1b/2 trial.

Lecia Bushak

May 13, 2024

12:09 pm

Source: Getty Images.

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Takeda Pharmaceuticals has had a busy few days and added a major transaction to the mix.

Takeda announced Monday morning that it will pick up an Alzheimer’s drug from neurodegenerative disease biotech AC Immune for $100 million upfront.

The drug, ACI-24.060, targets amyloid beta — the protein that builds up in the brain and marks Alzheimer’s — and seeks to clear plaque formation and delay the symptoms of the disease.

ACI-24.060 is currently being studied in a Phase 1b/2 trial dubbed ABATE, which will examine its safety, tolerability, immunogenicity and pharmacodynamic effects in people with prodromal Alzheimer’s as well as in people with Down syndrome.

Takeda will pay AC Immune $100 million upfront with the possibility of milestone payments up to $2.1 billion.

Takeda’s head of the neuroscience therapeutic area unit and head of global development, Sarah Sheikh, said in a statement that the drug was a “ground-breaking treatment approach” with the potential to offer patients a treatment with differentiated efficacy, safety and ease of administration.

Meanwhile, AC Immune CEO Andrea Pfeifer stated that the therapy could change the treatment paradigm for Alzheimer’s disease and address the multifaceted burden faced by patients and caregivers.

“We believe the maximum impact of ACI-24.060 can best be realized by partnering with Takeda at this critical juncture in its development, which will help us move rapidly into Phase 3,” Pfeifer added. “This agreement allows us to leverage the developmental expertise, strategic vision and financial capacity of an accomplished organization … while allowing us to focus on completing Phase 1b/2 development and accelerating our efforts to replicate this success with enhanced funding for our early-stage pipeline.”

This deal marks Takeda’s latest foray into the Alzheimer’s space, after it dropped a drug it was developing in collaboration with Denali Therapeutics last year.

That drug, TAK-920, reportedly had a “narrow therapeutic window” for the Alzheimer’s disease patient population, Denali said in a statement at the time.

The move also comes a week after Takeda announced it will undergo a $900 million restructuring after it reported a drop in profits partially linked to emerging generic competition. The pharma’s core revenue grew 1.5% at constant exchange rate (CER) in 2023, but its core operating profit declined 13.3%, it said.

Takeda CEO Christophe Weber noted during that announcement that the pharma expects to move up to six assets into Phase 3 development within the next fiscal year as part of the restructuring.

The drugmaker also recently made a sizable investment elsewhere in the neurodegenerative space.

Last September, Takeda paid $580 million to pick up AcuraStem’s amyotrophic lateral sclerosis (ALS) treatment program — including AS-202, an antisense oligonucleotide (ASO).

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Takeda nabs AC Immune Alzheimer’s therapy for $100M upfront

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